Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T224

(2~{S},3~{R},4~{R})-4-(1~{H}-indol-3-ylsulfanyl)-3-methyl-2-[(2~{S},3~{S})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid

Non-classical transpeptidases yield insight into new antibacterials.

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

National Institutes of Health/Office of the Director

peptidase, IgD_like domain, YkuD domain, TRANSFERASE-TRANSFERASE INHIBITOR complex

binding site for Di-peptide 6QR B 502 and CYS B 354