Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline

The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.

Kinesin-related motor protein Eg5, Kinesin-like spindle protein HKSP, Thyroid receptor-interacting protein 5, TRIP-5, Kinesin-like protein 1

15-17% PEG3350
150-300 mM NaNO3
100 mM MES, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K

protein-ligand complex, ATP-binding, Cell cycle, Cell division, Microtubule, Mitosis, Motor protein, Nucleotide-binding, Phosphoprotein