X-ray crystal structure of AmpC beta-lactamase from E. coli in complex with a non-covalent inhibitor 3-{[2-(4-CARBOXYPHENYL)ETHYL]SULFAMOYL}THIOPHENE-2-CARBOXYLIC ACID (compound 5)

3-{[2-(4-carboxyphenyl)ethyl]sulfamoyl}thiophene-2-carboxylic acid

Structure-based efforts to optimize a non-beta-lactam inhibitor of AmpC beta-lactamase.

1.7 M potassium phosphate, 3.5 mg/mL AmpC, pH 8.7, VAPOR DIFFUSION, HANGING DROP, temperature 296K

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

cephalosporinase, beta-lactamase, serine hydrolase, HYDROLASE-HYDROLASE INHIBITOR complex