SARS CoV2 Spike ectodomain with engineered trimerized VH binder

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike.

This reconstruction is a Gaussian low pass filtered map of a 3.2A gold standard FSC map, to better account for the VH density. The model was fit and relaxed into this map.

Same reconstruction as above but filtered based on the gold standard FSC to 3.2A. Shows high resolution features but density for the low occupancy VH is poorly resolved.

Complex of SARS CoV2 Spike ectodomain with engineered trimerized VH domain

Severe acute respiratory syndrome coronavirus 2

autonomous human heavy chain variable domain

Defense Advanced Research Projects Agency (DARPA)

autonomous human heavy chain variable domain, Spike glycoprotein
Spike, VH, SARS, CoV2, VIRAL PROTEIN-IMMUNE SYSTEM complex