RVD Q* recognizes 5hmC through water-mediated H bonds

2'-deoxy-5-(hydroxymethyl)cytidine 5'-(dihydrogen phosphate)

Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors.

DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*(5HC)P*GP*CP*GP*TP*CP*TP*CP*T)-3')

DNA (5'-D(*AP*GP*AP*GP*AP*CP*GP*CP*GP*AP*AP*GP*GP*GP*AP*CP*A)-3')

National Natural Science Foundation of China (NSFC)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES: WITH TLS ADDED

methylation TAL effector complex, DNA BINDING PROTEIN-DNA complex