Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit

cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera

cGMP-binding cGMP-specific phosphodiesterase, CGB-PDE, cGMP phosphodiesterase 6C

100 mM Tris, 200 mM MgSO4, 12% PEG-3350, 2.5% ethanol, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera (E.C.3.1.4.35)

mostly alpha, Allosteric enzyme, cGMP, cGMP-binding, Hydrolase, Magnesium, Metal-binding, Nucleotide-binding, Phosphoprotein, Cell membrane, Lipoprotein, Membrane, Methylation, Prenylation, Sensory transduction, Vision