ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core

The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.

5 subunit ORC complex with DNA bound in the core

DNA (5'-D(*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*AP*T)-3')

DNA (5'-D(*AP*TP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3')

Origin recognition complex subunit Latheo

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

analysis after streptactin affinity purification
cryoEM, initial 2D classification revealed the quaternary structure
replication, AAA+, ORC, DNA-binding, cryoEM, replication-DNA complex