LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)

Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.

Why Drinking Green Tea Could Prevent Cancer

Structural and Thermochemical Characterization of Lipoxygenase-Catechol Complexes

Structure of Soybean Lipoxygenase L3 and a Comparison with its L1 Isoenzyme

Position 713 is Critical for Catalysis But not Iron Binding in Soybean Lipoxygenase 3

PEG 8000, citrate-phosphate buffer, sodium azide, pH 5.3, VAPOR DIFFUSION, SITTING DROP, temperature 296K

Lipoxygenase-3 (soybean) in complex with 4-nitrocatechol

Lipoxygenase-3 (soybean) with 13HPOD (purple form)

Lipoxygenase-3 (soybean) with photodegradation product of curcumin (purple form)

HELIX
DETERMINATION METHOD: KABSCH & SANDER
(AUTHOR PROVIDED).

SHEET
DETERMINATION METHOD: KABSCH & SANDER
(AUTHOR PROVIDED).
STRAND: S1 1; N-TERMINAL 8-STRANDED
BETA BARREL.

SEQUENCE
SEQUENCE AS DEPOSITED FOR LOX3_SOYBN IN SWISS-PROT
P09186 WITH CHANGES AS FOR CV.PROVAR (REFERENCE 4).
SEQUENCES OF L3 IN STRAINS HAWKEYE AND PROVAR DIFFER
OF 5 AMINO ACIDS OUT OF 857. ALL 5 MUTATIONS ARE NOT
IN THE ACTIVE SITE REGION THAT IS HIGHLY CONSERVED.
SEQUENCE OF THE STRAIN BEESON-80 CULTIVAR IS NOT
DEPOSITED. NO EVIDENCE IN THE ELECTRON DENSITY MAP
HAS BEEN NOTICED THAT WOULD JUSTIFY ANY SUGGESTIONS
CONCERNING PRESENCE OF MUTATIONS.

METALLOPROTEIN, FE(II) COMPLEX, PURPLE LIPOXYGENASE, CATECHIN INHIBITOR, GREEN TEA, OXIDOREDUCTASE