Human PrimPol inserting correct dCTP opposite the 8-oxoguanine lesion

Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.

DNA (5'-D(P*AP*(8OG)P*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3')

DNA (5'-D(*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*CP*G)-3')

hPrimpol1,Coiled-coil domain-containing protein 111

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Ternary complex assembly 1
Chains A, C, D, E

Ternary complex assembly 2
Chains B, F, G, H

Translesion, DNA synthesis, DNA Replication, DNA damage, TRANSFERASE, TRANSFERASE-DNA complex