The internal aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A in complex with inhibitor 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (F9F) at the alpha-site and Cesium ion at the metal coordination site

2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE
N-(4'-TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1-ETHYLPHOSPHATE, F9

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Large plate-like crystal (0.20 x 0.25 x 0.35mm)

50 mM Bicine-CsOH, 8% PEG 8,000, 4 mM Spermine, pH 8.0

National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI)

Solvent flattening and Histogram matching

alpha2-beta2
Protein is a tetramer in solution and composed of two alpha-chains and two beta-chains.

LYASE, inhibitor complex, tryptophan synthase, LYASE-LYASE INHIBITOR complex