CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.

Structure and Functional Implications of the Polymerase Active Site Region in a Complex of HIV-1 RT with a Double-Stranded DNA template-primer and an Antibody Fab Fragment at 2.8 Angstroms Resolution

Touching the Heart of HIV-1 Drug Resistance: The Fingers Close Down on the dNTP at the Polymerase Active Site

30 % SATURATED AMMONIUM SULFATE, 100 MM CACODYLATE PH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 277K

UNLIGANDED MET184ILE HIV-1 REVERSE TRANSCRIPTASE

WILD-TYPE HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A DOUBLE STRANDED DNA TEMPLATE-PRIMER

HIV, REVERSE TRANSCRIPTASE, MET184ILE, 3TC, PROTEIN-DNA COMPLEX, DRUG RESISTANCE, M184I, TRANSFERASE-IMMUNE SYSTEM-DNA COMPLEX