Structure of Aurora-2 in complex with PHA-680626

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

SERINE/THREONINE KINASE 15, AURORA/IPL1-RELATED KINASE 1, AURORA-RELATED KINASE 1, HARK1, AURORA-A, BREAST-TUMOR-AMPLIFIED KINASE

30% PEG 5000MME, 0.2M SODIUM ACETATE 0.1M SODIUM CACODYLATE PH 6.5, 2MM DTT

CRYSTAL STRUCTURE OF AURORA-A PROTEIN KINASE

CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE

STRUCTURE OF AURORA-A 122-403, PHOSPHORYLATED ON THR287, THR288 AND BOUND TO TPX2 1-43

STRUCTURE OF UNPHOSPHORYLATED D274N MUTANT OF AURORA-A

STRUCTURE OF HUMAN AURORA-A 122-403 PHOSPHORYLATED ON THR287, THR288

AURORA-2 T287D T288D COMPLEXED WITH PHA- 680632

AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP

AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH A 5-AMINOPYRIMIDINYL QUINAZOLINE INHIBITOR

STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA -739358

GP IS PRESENT AT START DUE TO CLONING ARTIFACT

SERINE THREONINE-PROTEIN KINASE 6 (E.C.2.7.1.37, 2.7.11.1)

TRANSFERASE, PHOSPHORYLATION, NUCLEOTIDE-BINDING, KINASE, CELL CYCLE, ATP-BINDING, NUCLEOTIDE- BINDING, SERINE/THREONINE-PROTEIN KINASE, SERINE-THREONINE-PROTEIN KINASE