Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.

Cys255 modified by BME which is in the purification buffer

AH-related protein,Adenylate cyclase homolog,Germ cell soluble adenylyl cyclase,sAC,Testicular soluble adenylyl cyclase

100 mM sodium acetate pH 4.8
200 mM tri-sodium-citrate
15% (w/v) PEG 4000
10% (v/v) glycerol

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

human soluble Adenylyl Cyclase complex LRE1 inhibitor, LYASE