Cetuximab Fab in complex with 2-bromophenylalanine meditope variant

Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.

0.1 M citric acid, 0.1 M sodium hydrogen phosphate, 0.4 M potassium hydrogen phosphate, 1.6 M sodium dihydrogen phosphate

Cetuximab Fab light chain, Cetuximab Fab heavy chain, Meditope variant

binding site for Di-peptide GLN E 2 and 6DU E 3

binding site for Di-peptide 6DU E 3 and ASP E 4

binding site for Di-peptide GLN F 2 and 6DU F 3

binding site for Di-peptide 6DU F 3 and ASP F 4