Human cGAS catalytic domain bound with C20

2-[2-hydroxy-2-oxoethyl-[3-(7-methoxy-4-methyl-2-oxidanylidene-chromen-3-yl)propanoyl]amino]ethanoic acid

Discovery of novel cGAS inhibitors based on natural flavonoids.

cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1

18-20% V/V PEG 3350, 0.2 M AMMONIUM CITRATE