Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone

(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE

Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.

10mM BES, 0.1mM EDTA, pH 6.7, VAPOR DIFFUSION, temperature 298K

Glycogen phosphorylase, muscle form (E.C.2.4.1.1)

GLYCOGEN PHOSPHORYLASE, DIABETES, GLUCOSE, TRANSFERASE