Crystal structure of an idiotype-anti-idiotype Fab complex.

Preliminary Crystallographic Study of a Complex between an Fab of a Monoclonal Feline Peritonitis Virus Neutralizing Antibody and its Anti-Idiotype Fab

IDIOTYPIC FAB 730.1.4 (IGG1) OF VIRUS NEUTRALIZING ANTIBODY

FAB 730.1.4: LIGHT CHAIN VARIABLE REGION.
SEQUENTIAL RESIDUE NUMBERS KABAT RESIDUE NUMBERS
1 - 107 1 - 107

HEAVY CHAIN VARIABLE REGION.
SEQUENTIAL RESIDUE NUMBERS KABAT RESIDUE NUMBERS
1 - 52 1 - 52
53 52A
54 - 83 53 - 82
84 - 86 82A- 82C
87 - 104 83 - 100
105 - 108 100H- 100K
109 - 121 101 - 113

FAB 409.5.3: LIGHT CHAIN VARIABLE REGION
SEQUENTIAL RESIDUE NUMBERS KABAT RESIDUE NUMBERS
1 - 27 1 - 27
28 27A
29 - 108 28 - 107

HEAVY CHAIN VARIABLE REGION
SEQUENTIAL RESIDUE NUMBERS KABAT RESIDUE NUMBERS
1 - 52 1 - 52
53 - 55 52A- 52C
56 - 85 53 - 82
86 - 88 82A- 82C
89 - 106 83 - 100
107 - 108 100A- 100B
109 - 121 101 - 113

IDIOTYPIC FAB 730.1.4 (IGG1) OF VIRUS NEUTRALIZING ANTIBODY, ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A)

COMPLEX (IMMUNOGLOBULIN IGG1-IGG2A), COMPLEX (IMMUNOGLOBULIN IGG1-IGG2A) complex