Crystal structure of rabbit LDHA in complex with AP27460

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.

Lactate dehydrogenase A, LDHA, LDH-A, LDH muscle subunit, LDH-M

0.1 M Tris, pH 8.0, 30% PEG550 MME, VAPOR DIFFUSION, HANGING DROP, temperature 277K

L-lactate dehydrogenase A chain (E.C.1.1.1.27)

fragment, inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex