3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine

2-{6-[(4aS,6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]hexyl}-1 ,2-benzisothiazol-3(2H)-one 1,1-dioxide
2-[6-[(4aS,6R,8aS)-4a,5,9,10-tetrahydro-6-hydroxy-3-methoxy-6H-benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]hexyl]-1,2- benzisothiazol-3(2H)-one 1,1-dioxide

Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives.

The complex of a bivalent derivative of galanthamine with Torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design

Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3A resolution

Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs

Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking

Galanthamine as bis-functional ligand for the acetylcholinesterase.

A QXP-based multistep docking procedure for accurate prediction of protein-ligand complexes

Three-segment Pt-coated toroidal mirrors

42% PEG200, 100mM MES pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K

Complex of TcAChE with bis-acting Galanthamine derivative

Complex of TcAChE with Galanthamine derivative

Acetylcholinesterase (E.C.3.1.1.7) complexed with Galanthamine

Orthorhombic form of Torpedo californica Acetylcholinesterase(AChE) complexed with bis-acting Galanthamine derivative

Structure of Acetylcholinesterase with (-)-Galanthamine at 2.3A resolution

3D structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropylgalanthamine

Bulk solvent modeling method used: Flat model

Serine hydrolase, Cholinesterase, Neurotransmitter degradation, Alzheimer's disease, Bis-functional galanthamine derivative, Alternative splicing, Cell junction, Cell membrane, Disulfide bond, Glycoprotein, GPI-anchor, Hydrolase, Lipoprotein, Membrane, Serine esterase, Synapse