CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 9

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.

55 kDa actin-bundling protein,Singed-like protein,p55

U VALUES : WITH TLS ADDED HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

actin bundling, small molecule inhibition, STRUCTURAL PROTEIN