Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

DNA topoisomerase IV subunit B ParE, FTL_1726
Francisella tularensis subsp. holarctica

10% PEG 4000, 10% isopropanol, 100 mM citrate, pH 5.4, VAPOR DIFFUSION, HANGING DROP, temperature 277K

THIS RESIDUES REPRESENTS A NATURAL VARIANT

Topoisomerase IV, subunit B (E.C.5.99.1.3)

ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, isomerase-isomerase inhibitor complex