Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.

Alpha,alpha-trehalose-phosphate synthase (UDP-forming)

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)

0.1 M sodium malonate, 0.1 M Tris, 30% PEG 1000

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

The region of Ser38 to Gly40 is relatively flexible and shows scattered density. Even though these two residues have been built slightly farther away from each other, this does not affect the overall interpretation of this structure

trehalose-6-phosphate phosphatase (E.C.2.4.1.15)

trehalose-6-phosphate synthase, TRANSFERASE