Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and validoxylamine A

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Trehalose-6-phosphate synthase,UDP-glucose-glucosephosphate glucosyltransferase

Candida albicans (strain SC5314 / ATCC MYA-2876)

0.2 M lithium sulfate, 0.1 M Tris, 40% PEG 400

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

trehalose-6-phosphate phosphatase (E.C.2.4.1.15)

trehalose-6-phosphate synthase, TRANSFERASE