Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

(3S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11

12% PEG 3350, 0.2M NaMalonate, pH 4.0, vapor diffusion, hanging drop, temperature 289K

Caspase-6, active, VEID, uncompetitive inhibition, ternary complex, Caspase, protease, HYDROLASE-HYDROLASE INHIBITOR complex

chain A and (resseq 31:175 or resseq 198:291 ) and (not element H)

chain B and (resseq 31:175 or resseq 198:291 ) and (not element H)

BINDING SITE FOR CHAIN C OF VEID INHIBITOR

BINDING SITE FOR CHAIN D OF VEID INHIBITOR