Human GRK2 in complex with Gbetagamma subunits and CCG224062

Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Beta-ARK-1, G-protein coupled receptor kinase 2

50 mM MES, 0.8-1.2 M sodium chloride, 8-16% PEG3350

National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)

Michigan Economic Development Corporation and Michigan Technology Tri-Corridor Grant

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

RGS, kinase, PH, WD-40, inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex