Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2

Structural basis for therapeutic inhibition of complement C5.

Chains A and B are the product of a single gene that is processed into two chains that remain covalently linked via a disulphide.

N-terminal residues are His-tag from vector

First 3 residues are remnants of expression tag. Native mature sequence starts EEAN.

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4

10% (w/v) PEG 20K, 2%(v/v)1,4 Dioxane, 0.1M Bicine pH 9.0

Netherlands Organisation for Scientific Research

chain 'A' and (resid 1515 through 1676 )

Complement C5, Complement inhibitor, Rhipicephalus microplus RaCI2

Complement, Inflammation, Inhibitor, Tick, immune system