Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA poymerase II CTD peptide phosphorylated at SER-7

An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1.6M ammonium chloride, 27% (w/v) PEG 3350, 10mM Sodium potassium tartrate,, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (E.C.3.1.3.16), Pol II CTD peptide

Heat repeat, phosphatase, RNA polymerase II, HYDROLASE