Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151)

(2S)-3-METHYL-2-((2R,3S)-3-[(METHYLSULFONYL)AMINO]-1-{[2-(PYRROLIDIN-1-YLMETHYL)-1,3-OXAZOL-4-YL]CARBONYL}PYRROLIDIN-2-YL)BUTANOIC ACID

Discovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151)

ELASTASE, NEUTROPHIL ELASTASE, PMN ELASTASE, BONE MARROW SERINE PROTEASE, MEDULLASIN

HNE/GW475151 COMPLEX 10MG/ML IN 10MM NA CITRATE PH 5.0. HANGING DROPS OF EQUAL VOLUMES OF PROTEIN AND PRECIPITANT. PRECIPITANT 1.1-1.2M AMMONIUM SULPHATE, 100MM CITRATE PH 3.8-4.0, ROOM TEMP.

CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE WITH MDL 101, 146

HUMAN NEUTROPHIL ELASTASE (HNE) (ALSO REFERRED TO AS HUMAN LEUCOCYTE ELASTASE (HLE)) COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-ALA CHLOROMETHYL KETONE (MSACK)

HUMAN LEUKOCYTE ELASTASE (HLE) (NEUTROPHIL ELASTASE (HNE)) COMPLEX WITH THE THIRD DOMAIN OF TURKEY OVOMUCOID INHIBITOR (OMTKY3)

HUMAN LEUKOCYTE ELASTASE (HLE) COMPLEX WITH MEO-SUCCINYL-ALA-ALA-PRO-VAL CHLOROMETHYLACETONE

SHEET
DETERMINATION METHOD: DSSP
THE SHEETS PRESENTED AS "AA" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY
A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.

THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 14-STRANDED BARREL THIS IS REPRESENTED BY
A 15-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.

THE SHEETS PRESENTED AS "BA" IN EACH CHAIN ON SHEET RECORDS
BELOW IS ACTUALLY AN 6-STRANDED BARREL THIS IS REPRESENTED BY
A 7-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS
ARE IDENTICAL.