Crystal structure of SARS-CoV-2 main protease in complex with cpd-11

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.

3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase

Severe acute respiratory syndrome coronavirus 2

300 mM sodium nitrate, 300 mM disodium hydrogen phosphate, 300 mM ammonium sulphate, 100 mM MES/imidazole pH 6.5, 10% (w/v) PEG550 MME and 20% (w/v) PEG 20K

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket at the crystallization facility of Swiss Light Source