Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD

Structure of the ternary signaling complex of a TGF-beta superfamily member.

NDG C 402 HAS WRONG CHIRALITY AT ATOM C1

Bone morphogenetic protein receptor type IA

Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, CD292 antigen

4M sodium formate, 100mM Hepes, 3% dioxane, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K

Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, Activin receptor type 2A

The asymmetric unit consists of two subunits, each subunit is one half of the biological dimer. The second half of the dimer is generated by the 2-fold axis: y, x, (z-1) + 2/3

TGF-beta, BMP-2, BMPR-Ia, ActRII, ALK-3, TRANSFERASE