CRYSTAL STRUCTURE OF AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH NON-BETA-LACTAMASE INHIBITOR (2, 3-(4-BENZENESULFONYL-THIOPHENE-2-SULFONYLAMINO)-PHENYLBORONIC ACID)

3-(4-BENZENESULFONYL-THIOPHENE-2-SULFONYLAMINO)-PHENYLBORONIC ACID

Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase.

1.7 M potassium phosphate, 95 uM AmpC, 600 uM compound 2 (ET011), pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 296K

cephalosporinase, beta-lactamase, serine hydrolase, HYDROLASE