Structure of hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoMet

3-FLUOROMETHYL 7-THIOMORPHOLINOSULFONAMIDE 1,2,3,4-TETRAHYDROISOQUINOLINE

Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase

PNMTase, Noradrenaline N-methyltransferase

PEG6K, LiCl, cacodylate, pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 293K

The same protein with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)

The same protein with inhibitor 3-fluoromethyl-7-trifluoropropyl-THIQ and AdoHc

Phenylethanolamine N-methyltransferase (E.C.2.1.1.28)