Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab

One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta

heavy chain of antibody binding fragment of canakinumab

light chain of antibody binding fragment of canakinumab

17.2% w/v PEG 3350 and 0.14M tri-sodium citrate, 24% w/v PEG 3350, pH 4.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K

antibody binding fragment in its unbound state

Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab

immunglobulin fold, interleukin-1beta binding, IMMUNE SYSTEM