Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.

PEG 3350, POTASSIUM PHOSPHATE, n-TETRADECYL-BETA-D-MALTOSIDE, SODIUM CHLORIDE , pH 7.3, VAPOR DIFFUSION, HANGING DROP, temperature 298K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

AUTHORS STATE THIS IS A MEMBRANE BOUND PROTEIN THAT IS FUNCTIONALLY A MONOMER AND FORMS COMPLEX WITH THE ELECTRON DONOR PARTNER CYTOCHROME P450 REDUCTASE.

sterol 14-alpha demethylase, CYP51, cytochrome P450, heme, oxidoreductase, monooxygenase, membrane protein, sterol biosynthesis