crystal structure of KSP in complex with inhibitor 9h

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

Kinesin-related motor protein Eg5, Kinesin-like spindle protein HKSP, Thyroid receptor-interacting protein 5, TRIP5, Kinesin-like protein 1

PEG3350, potassium phosphate, pH 8, VAPOR DIFFUSION, HANGING DROP, temperature 277K

This motor domain is a part of a multi-domain protein (KSP) that forms a tetramer. There are two motor domain monomers in an asymetric unit.