Structure of rat neuronal nitric oxide synthase M336V D597N mutant heme domain in complex with 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN- 3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE

Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.

BNOS, CONSTITUTIVE NOS, NC-NOS, NOS TYPE I, NEURONAL NOS, N-NOS, NNOS, PEPTIDYL-CYSTEINE S-NITROSYLASE NOS1

OVERALL RMERGE 0.155 RPIM 0.105 CC ONE HALF 0.995 HIGHEST RESOLUTION SHELL RMERGE 1.998 RPIM 1.353 CC ONE HALF 0.451

20-24% PEG3350, 0.1M MES 0.14-0.20M AMMONIUM ACETATE, 10% ETHYLENE GLYCOL, 30UM SDS 5 MM GSH, pH 5.8

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH N1-(5-(2-(6- AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)-N1, N2-DIMETHYLETHANE-1,2-DIAMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-( 5-(4-METHYLPIPERAZIN-1-YL)PYRIDIN-3-YL)ETHYL)PYRIDIN -2-AMINE

RESIDUES 339-349 IN CHAIN A AND 339-347 IN CHAIN B ARE DISORDERED.

NITRIC OXIDE SYNTHASE, BRAIN (E.C.1.14.13.39)

OXIDOREDUCTASE, NITRIC OXIDE SYNTHASE, INHIBITOR COMPLEX