Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide

A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro.

Azoreductase,DT-diaphorase,DTD,Menadione reductase,NAD(P)H:quinone oxidoreductase 1,Phylloquinone reductase,Quinone reductase 1,QR1

0.2 M magnesium chloride hexahydrate, 20% w/v polyethylene glycol 3350, pH 5.9

NAD(P)H dehydrogenase [quinone] 1 (E.C.1.6.5.2)

flavoprotein ligand complex quinone reduction oxidative stress drug metabolism, OXIDOREDUCTASE