Acinetobacter baylyi LptB2FG bound to lipopolysaccharide and Zosurabalpin

4-{(7S,10S,13S)-10-(4-aminobutyl)-7-(3-aminopropyl)-13-[(1H-indol-3-yl)methyl]-12-methyl-8,11,14-trioxo-5,6,7,8,9,10,11,12,13,14,15,16-dodecahydropyrido[2,3-b][1,5,8,11,14]benzothiatetraazacycloheptadecin-17-yl}benzoic acid

A new antibiotic traps lipopolysaccharide in its intermembrane transporter

300 mM NaCl, 20 mM Tris [pH 7.4], 0.02% GDN, 0.25 mM tris(hydroxypropyl)phosphine

Inner membrane lipopolysaccharide transporter composed of LptF, LptG and two molecules of LptB in complex with lipopolysaccharide and Zosurabalpin

This sample was monodisperse as determined by SEC.

Lipopolysaccharide export system ATP-binding protein LptB

Lipopolysaccharide export system permease protein LptF

LPS export ABC transporter permease LptG

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

lipopolysaccharide, ABC, ATPase, antibiotic, macrocyclic peptide, gram-negative bacteria, ESKAPE, LIPID TRANSPORT