PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P07B06 from the F2X-Universal Library

Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.

PRP8, DBF3, DNA39, RNA8, SLT21, USA2, YHR165C

19% PEG4000, 3% DMSO, 0.1 M Tris, pH 8.5, 0.2 M lithium sulfate

Aar2/RNaseH complexed with fragments of the F2X-Universal Library. Deposited are the PanDDA bound state models after inspection and ligand placement based on PanDDA event maps. The event maps are included in the mmcif and are the determining evidence for the ligands. 2FoFc and FoFc maps will be mostly not useful to consider here.

FRAGMAX, FRAGMAXAPP, fragment screening, RNaseH like domain, U5 SNRNP assembly, SPLICING