Crystal structure of KNI-10006 bound histo-aspartic protease (HAP) from Plasmodium falciparum

Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum.

AUTHORS STATE THAT THE VALUE OF RMERGE IN THE HIGHEST RESOLUTION SHELL IS HIGH DUE TO POORLY DIFFRACTING CRYSTAL/HIGH SYMMETRY SPACE GROUP/HIGHLY REDUNDANT DATA. CRYSTAL HAS SUFFERED SOME RADIATION DAMAGE

0.2M KH2PO4, 20% PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 293K

Crystal structure of histo-aspartic protease (HAP) from Plasmodium Falciparum

Crystal structure of pepstatin A bound histo-aspartic protease from Plasmodium falciparum

Four molecules of histo-aspartic protease (HAP) are present in the asymmetric unit. These four molecules are present as two dimers. Each protein molecule is complexed to one KNI-10006 molecule.

Histo-aspartic protease, HYDROLASE, Plasmepsin, Aspartic protease, KNI, KNI-10006, HYDROLASE-HYDROLASE INHIBITOR COMPLEX