Crystal structure of RIG-I in complex with Cap-0 RNA

Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.

Probable ATP-dependent RNA helicase DDX58

RNA (5'-R(P*GP*AP*AP*UP*AP*UP*AP*AP*UP*AP*GP*UP*GP*AP*UP*AP*UP*UP*AP*UP*AP*UP*UP*C)-3')

DEAD box protein 58,RIG-I-like receptor 1,RLR-1,Retinoic acid-inducible gene 1 protein,RIG-1,Retinoic acid-inducible gene I protein,RIG-I

20% (w/v) PEG 3350, 0.2 M NaSCN, 100 mM MOPS (pH 7.8), 3.5% (v/v) 2,2,2-trifluoroethanol

Probable ATP-dependent RNA helicase DDX58/RNA Complex
Complex, RIG-I, capped RNA, self versus non-self, innate immunity, hydrolase-rna complex
binding site for Di-nucleotide M7G D 101 and G D 2
binding site for Di-nucleotide M7G F 101 and G F 2
binding site for Di-nucleotide M7G H 101 and G H 2
binding site for Di-nucleotide M7G J 101 and G J 2
binding site for Di-nucleotide M7G L 101 and G L 2