PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.

Serine/threonine-protein kinase VRK1 N-terminus peptide

2.5M Ammonium Sulfate
90mM Bis-Tris Propane, pH 6.3
4% Pentaerythritol ethoxylate (3/4 EO/OH)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Cancer Prevention and Research Institute of Texas (CPRIT)

Methyl-lysine binding, aromatic cage, plant homeodomain, PHD, Jumonji domain, plant homeodomain finger 2, PHF2, histone H3 lysine 4 tri-methylation, H3K4me3, PROTEIN BINDING, OXIDOREDUCTASE-TRANSFERASE complex