Crystal structure of human GRP78 (70kDa heat shock protein 5 / BIP) ATPase domain in complex with 2'-deoxy-ADP and inorganic phosphate

Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.

GRP-78, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, BiP

24-26% PEG3350, 0.1 M Tris-HCl, 0.2 M sodium chloride

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Chaperone, ATPase domain, nucleotide-binding, endoplasmic reticulum