Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT

6-[3-hydroxy-2-(hydroxymethyl)propyl]-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, N-methyl-DHBT

Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.

Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.

The three-dimensional structure of thymidine kinase from herpes simplex virus type 1.

Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.

Herpes simplex virus (type 1 / strain 17)

0.9-1.2M Li2SO4, 1mM DTT, 0.1M HEPES pH 7.5-8.0, VAPOR DIFFUSION, SITTING DROP, temperature 296K

Thymidine kinase from herpes simplex virus type 1 complexed with DHBT

Thymidine kinase from herpes simplex virus type 1 in the apo form

Transferase, thymidine kinase, DNA-synthesis, PET tracer, ATP-binding, DNA synthesis, Early protein, Nucleotide-binding