Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative

hydantoin derivatives as Non-pepridic inhibitors of Ras Farnesyl transferase

Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit

Protein farnesyltransferase beta subunit

CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha

CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta

0.1M Na Aetate, pH 5.1, 0.2M NaCl, 10% isopropyl alcohol , pH 5.3, VAPOR DIFFUSION, HANGING DROP, temperature 295K

Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (E.C.2.5.1.58, 2.5.1.59), Protein farnesyltransferase beta subunit (E.C.2.5.1.58)

The biological assembly is the dimer of alpha and beta subunits.