X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Phac-Cit-Val-Arg-Amba

X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.

Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE

CRYSTALLIZATION SOLUTION: 100mM MES, 200mM K/NaH2PO4, PH 5.5-6.0, 3-4M NaCl, 3% DMSO; RESERVOIR SOLUTION: 3-4 M NaCl

Protease, Inhibitor, Complex, Proprotein convertase, Citrullin, HYDROLASE

binding site for residues HY1 D 1 and CIR D 2