Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7

Affinity-Based Probes Based on Type II Kinase Inhibitors.

Side scattering bent cube-root I-beam single crystal; asymmetric cut 4.965 degs

0.1 M NaCacodylate pH 6.25, 0.24 M CaAcetate, 50% PEG 300, vapor diffusion, sitting drop, temperature 277K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES: WITH TLS ADDED

Serine/threonine-protein kinase 10 (E.C.2.7.11.1)

serine/threonine kinase, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex