THE 2.7 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH FLURBIPROFEN

Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.

PEG-4000, sodium chloride, beta-octyl glucoside, potassium phosphate (dibasic), pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 18K

THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN

PROSTAGLANDIN H SYNTHASE-1 (E.C.1.14.99.1)

The biological assembly is a dimer constructed from chain A and chain B, related by 2-fold NCS symmetry

EGF DOMAIN, NSAID Binding, Flurbiprofen, Membrane-Binding Domain, Cyclooxygenase, Peroxidase, Oxidoreductase, Dioxygenase