Crystal structure the Fab fragment of Efalizumab

Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance.

15mM citric acid, 12% w/v PEG 3350, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K

Efalizumab Fab fragment, light chain, Efalizumab Fab fragment, heavy chain

Efalizumab, Fab, antibody, IMMUNE SYSTEM