QUINOLONE-STABILIZED CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM KLEBSIELLA PNEUMONIAE

(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.

DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A

Topoisomerase IV subunit B,Topoisomerase IV subunit A

0.1 M TRIS PH 7.5-8.0, 0-50 MM NACL,
4-8% PEG4000 AND 12-15% GLYCEROL, VAPOR DIFFUSION, HANGING DROP,
TEMPERATURE 298K

Biotechnology and Biological Sciences Research Council

INHIBITOR-STABILISED CLEAVAGE COMPLEX OF TOPOISOMERASE IIA FROM S. PNEUMONIAE (LEVOFLOXACIN)

PD0305970-STABILISED CLEAVAGE COMPLEX OF TOPO IV FROM S. PNEUMONIAE

INHIBITOR-STABILISED CLEAVAGE COMPLEX OF TOPOISOMERASE IIA FROM S. PNEUMONIAE (CLINAFLOXACIN)

INHIBITOR-STABILISED CLEAVAGE COMPLEX OF TOPOISOMERASE IIA FROM S. PNEUMONIAE (PD 0305970)

A THREE-GATE STRUCTURE OF TOPOISOMERASE IV FROM STREPTOCOCCUS PNEUMONIAE

THE SEQUENCES FOR BOTH PARC AND PARE SUBUNITS IN THIS STRUCTURE ARE FROM KLEBSIELLA PNEUMONIAE STRAIN ATCC 35657. THE SUBUNITS ARE CONNECTED BY A TWO RESIDUE LINKER EF. A SIX RESIDUE HIS TAG IS IN THE C-TERMINUS.

(CHAIN K AND RESID 8:15 ) OR (CHAIN L AND (RESID 1:12 OR RESID 102:103 ) )

(CHAIN A AND (RESID 400:523 OR RESID 566:595 OR RESID 622:624 ) )

(CHAIN B AND (RESID 400:523 OR RESID 566:595 OR RESID 622:624 ) )

(CHAIN G AND (RESID 400:523 OR RESID 566:595 OR RESID 622:623 ) )

(CHAIN J AND (RESID 400:523 OR RESID 566:595 OR RESID 622:624 ) )

(CHAIN E AND RESID 8:15 ) OR (CHAIN F AND (RESID 1:12 OR RESID 100:100 ) ) OR (CHAIN A AND RESID 1502 )

(CHAIN C AND RESID 8:15 ) OR (CHAIN D AND (RESID 1:12 OR RESID 100:100 ) ) OR (CHAIN L and RESID 101 )

(CHAIN I AND (RESID 1:12 OR RESID 100:100 ) ) OR (CHAIN H AND RESID 8:15 ) OR (CHAIN G AND RESID 1502 )

DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A/DNA Complex
KLEBSIELLA PNEUMONIAE, CLEAVAGE COMPLEX, QUINOLONE, LEVOFLOXACIN, TOPOISOMERASE IV, DNA BINDING, ISOMERASE, ISOMERASE-DNA COMPLEX